7-乙氧基-6-甲氧基-2,2-二甲基-2,3-二氢-4H-苯并吡喃-4-酮合成路线 （共 12 条）
反应条件
hydrogenchloride; lithium aluminium tetrahydride 1.) ether, reflux, 1 h, 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Timar, Tibor; Jaszberenyi, J. Csaba
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 871 - 877
反应条件
potassium carbonate in acetone
参考文献
Alkaloida Vegyeszeti Gyar
Patent: US4866089 A1, 1989 ;
反应条件
trifluoroacetic acid
T=80°C; 1 h;
参考文献
Chaturvedi, R.; Mulchandani, N. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 6 p. 338 - 339
反应条件
1: 79 percent / unfused ZnCl2 with 5percent water, POCl3 / 5 h / 50 °C
2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C
3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C
View Scheme
参考文献
Timar, Tibor; Jaszberenyi, J. Csaba
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 871 - 877
反应条件
1: 79 percent / unfused ZnCl2 with 5percent water, POCl3 / 5 h / 50 °C
2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C
3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C
View Scheme
参考文献
Timar, Tibor; Jaszberenyi, J. Csaba
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 871 - 877
反应条件
1: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C
2: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C
View Scheme
参考文献
Timar, Tibor; Jaszberenyi, J. Csaba
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 871 - 877
反应条件
1: 92 percent / 1.) 5percent aq. NaOH; 2.) conc. HCl / 1 h / 25 °C
2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C
3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C
View Scheme
参考文献
Timar, Tibor; Jaszberenyi, J. Csaba
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 871 - 877
反应条件
1: 85 percent / Mg / benzene / 9 h / Heating
2: 22 percent / K2CO3 / hexane / 20 h / Irradiation
3: 98 percent / 10percent aq. NaOH / hexane / 4 h / Ambient temperature
4: 60 percent / ethanol / 3 h
5: 85 percent / 25percent aq. NaOH, 20percent aq. Et4NOH / 1 h / 60 - 65 °C
View Scheme
参考文献
Miranda, Miquel A.; Primo, Jaime; Tormos, Rosa
Heterocycles, 1991 , vol. 32, # 6 p. 1159 - 1166
反应条件
1: 85 percent / Mg / benzene / 9 h / Heating
2: 22 percent / K2CO3 / hexane / 20 h / Irradiation
3: 98 percent / 10percent aq. NaOH / hexane / 4 h / Ambient temperature
4: 60 percent / ethanol / 3 h
5: 85 percent / 25percent aq. NaOH, 20percent aq. Et4NOH / 1 h / 60 - 65 °C
View Scheme
参考文献
Miranda, Miquel A.; Primo, Jaime; Tormos, Rosa
Heterocycles, 1991 , vol. 32, # 6 p. 1159 - 1166
反应条件
1: 60 percent / ethanol / 3 h
2: 85 percent / 25percent aq. NaOH, 20percent aq. Et4NOH / 1 h / 60 - 65 °C
View Scheme
参考文献
Miranda, Miquel A.; Primo, Jaime; Tormos, Rosa
Heterocycles, 1991 , vol. 32, # 6 p. 1159 - 1166
