in tetrahydrofuran

1: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C 2: 1.) NaBH4; 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h; 2.) THF, 25 deg C, 1.5 h View Scheme

1: 79 percent / unfused ZnCl2 with 5percent water, POCl3 / 5 h / 50 °C 2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C 3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C 4: 1.) NaBH4; 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h; 2.) THF, 25 deg C, 1.5 h View Scheme

1: 79 percent / unfused ZnCl2 with 5percent water, POCl3 / 5 h / 50 °C 2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C 3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C 4: 1.) NaBH4; 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h; 2.) THF, 25 deg C, 1.5 h View Scheme

1: SeO2, 30percent aq. H2O2 / CH2Cl2 / 36 h / Ambient temperature 2: 5percent methanolic KOH / methanol 3: K2CO3 / acetone View Scheme

1: 5percent methanolic KOH / methanol 2: K2CO3 / acetone View Scheme

1: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C 2: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C 3: 1.) NaBH4; 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h; 2.) THF, 25 deg C, 1.5 h View Scheme

1: 92 percent / 1.) 5percent aq. NaOH; 2.) conc. HCl / 1 h / 25 °C 2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C 3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C 4: 1.) NaBH4; 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h; 2.) THF, 25 deg C, 1.5 h View Scheme

1: 85 percent / Mg / benzene / 9 h / Heating 2: 22 percent / K2CO3 / hexane / 20 h / Irradiation 3: 98 percent / 10percent aq. NaOH / hexane / 4 h / Ambient temperature 4: 60 percent / ethanol / 3 h 5: 85 percent / 25percent aq. NaOH, 20percent aq. Et4NOH / 1 h / 60 - 65 °C 6: 1.) LiAlH4, 2.) 6 M aq. HCl / 1.) ether, reflux, 1 h, 2.) reflux, 10 min View Scheme

1: 85 percent / Mg / benzene / 9 h / Heating 2: 22 percent / K2CO3 / hexane / 20 h / Irradiation 3: 98 percent / 10percent aq. NaOH / hexane / 4 h / Ambient temperature 4: 60 percent / ethanol / 3 h 5: 85 percent / 25percent aq. NaOH, 20percent aq. Et4NOH / 1 h / 60 - 65 °C 6: 1.) LiAlH4, 2.) 6 M aq. HCl / 1.) ether, reflux, 1 h, 2.) reflux, 10 min View Scheme