sodium cyanoborohydride; chloroacetic acid in methanol 1 h; Ambient temperature;

1: 100 percent / K2CO3 / diethyl ether; H2O / ice bath 2: sodium ethanolate / ethanol; diethyl ether / 15 h / Ambient temperature 3: 90 percent / acetonitrile; H2O / 2 h / 70 °C 4: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature View Scheme

1: 90 percent / acetonitrile; H2O / 2 h / 70 °C 2: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature View Scheme

1: sodium ethanolate / ethanol; diethyl ether / 15 h / Ambient temperature 2: 90 percent / acetonitrile; H2O / 2 h / 70 °C 3: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature View Scheme