2,6-二甲基-1,4-苯二酚合成路线 （共 58 条）
反应条件
sodium acetate in methanol; water T=24°C; Equilibrium constant;
参考文献
Brown,E.R. et al.
Journal of Organic Chemistry, 1971 , vol. 36, # 19 p. 2849 - 2853
反应条件
sulfuric acid in methanol
T=100°C; 4 h;
参考文献
Zhao, Wenjun; Huang, Li; Guan, Yong; Wulff, William D.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3436 - 3441
Angew. Chem., 2014 , vol. 126, # 13 p. 3504 - 3509,6
反应条件
sulfuric acid
Heating;
参考文献
Chen, Yuanwei; Reymond, Jean-Louis; Lerner, Richard A.
Angewandte Chemie, 1994 , vol. 106, # 15/16 p. 1694 - 1696
反应条件
1: sulfuric acid / 1.7 h / 20 °C / |Inert atmosphere
2: sodium dithionite; sodium hydroxide / water; ethanol / 0.67 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Zhao, Wenjun; Huang, Li; Guan, Yong; Wulff, William D.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3436 - 3441
Angew. Chem., 2014 , vol. 126, # 13 p. 3504 - 3509,6
反应条件
1: 73 percent / K2CO3 / dimethylformamide; toluene / 80 °C
2: 55 percent / BBr3 / CH2Cl2 / 0.5 h / 20 °C
3: 75 percent / K2CO3 / acetone / 12 h / 20 °C
View Scheme
参考文献
Punna, Sreenivas; Meunier, Stephane; Finn
Organic Letters, 2004 , vol. 6, # 16 p. 2777 - 2779
反应条件
1: 95 percent / ImH / dimethylformamide / 12 h / 60 °C
2: NBS, AIBN / CCl4 / 2 h / 77 °C / Irradiation
3: LDA / tetrahydrofuran / 2 h / 0 - 24 °C
4: Bu4NF / tetrahydrofuran / 7 h / 0 °C
5: MeI / acetonitrile / 1.5 h / 80 °C
6: aq. CuCl2 / tetrahydrofuran / 4 h / 23 °C
7: 2.) AcOH / 1.) THF, from -78 to 0 deg C, 12 h
8: H2 / Pd/C / ethyl acetate / 6 h / 23 °C / 2068.6 Torr
9: 69 percent / aq. NO(KSO3)2, KH2PO4 / acetone / 2 h / 23 °C
View Scheme
参考文献
Falck; Chandrasekhar; Manna, Sukumar; Chiu, Ching-Chen S.; Mioskowski, Charles; Wetzel, Isabelle
Journal of the American Chemical Society, 1993 , vol. 115, # 24 p. 11606 - 11607
反应条件
dihydrogen peroxide in 1,4-dioxane; water
T=56.84°C; 1 h; Catalytic behavior; Reagent/catalyst; Overall yield = 96.4 percent;
参考文献
Selvaraj; Park; Kim
Dalton Transactions, 2014 , vol. 43, # 3 p. 958 - 966
反应条件
[bis(acetoxy)iodo]benzene
参考文献
Lu; Shoemaker; Wheeler
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 6993 - 6996
