6-甲基-3-氰基-4-三氟甲基-2-羟基吡啶合成路线 （共 6 条）
反应条件
diethylamine in ethanol 2.5 h; Reflux;
参考文献
Gueden-Silber, Tuba; Klein, Kathrin; Seitz, Michael
Dalton Transactions, 2013 , vol. 42, # 38 p. 13882 - 13888
参考文献
Basheer, Ahmad; Rappoport, Zvi
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1386 - 1396
反应条件
in methanol 6 h; Heating;
参考文献
Journal of Fluorine Chemistry, , vol. 118, # 1-2 p. 73 - 79
反应条件
1: sulfuric acid / water / 20 h / 150 °C 2: neat (no solvent) / 7 h / 160 °C / |Inert atmosphere View Scheme
参考文献
Dalton Transactions, , vol. 42, # 38 p. 13882 - 13888
反应条件
trichlorophosphate 2 h; Reflux;
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
Location in patent: Paragraph 00402; 00404 ;
反应条件
sulfuric acid in water T=150°C; 20 h;
参考文献
Gueden-Silber, Tuba; Klein, Kathrin; Seitz, Michael
Dalton Transactions, 2013 , vol. 42, # 38 p. 13882 - 13888
