5-溴-2-三氟甲基苯甲酸合成路线 （共 2 条）
反应条件
1: With water; sodium hydroxide in methanol
T=55°C; 2 h;
2: With hydrogenchloride in water
pH=5;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2009/89042 A1, 2009 ;
Location in patent: Page/Page column 101 ;
WO 2009/089042 A1
反应条件
triethylamine tris(hydrogen fluoride) in N,N-dimethyl-formamide
T=23°C; 0.166667 h; Inert atmosphere;
参考文献
Lishchynskyi, Anton; Novikov, Maxim A.; Martin, Eddy; Escudero-Adan, Eduardo C.; Novak, Petr; Grushin, Vladimir V.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11126 - 11146
