反应条件
1.1: 100 percent / sodium cyanoborohydride; aq. acetic acid / 20 °C
2.1: trifluoroacetic acid / CH2Cl2 / 20 °C
3.1: 57 percent / trifluoroacetic acid / methanol / 70 °C
4.1: 76 percent / LiAlH4 / tetrahydrofuran / 20 °C
5.1: 93 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 0 °C
6.1: BuLi / tetrahydrofuran; hexane / -78 °C
6.2: 88 percent / tetrahydrofuran; hexane / 20 °C
7.1: 31 percent / LiAlH4 / tetrahydrofuran / 20 °C
View Scheme
参考文献
Ranatunge, Ramani R.; Augustyniak, Michael; Bandarage, Upul K.; Earl, Richard A.; Ellis, James L.; Garvey, David S.; Janero, David R.; Letts, L. Gordon; Martino, Allison M.; Murty, Madhavi G.; Richardson, Stewart K.; Schroeder, Joseph D.; Shumway, Matthew J.; Tam, S. William; Trocha, A. Mark; Young, Delano V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2180 - 2193
