2,4-二氯-6-甲基苯甲酸合成路线 (共 4 条)
反应条件
1: 2,4-dichloro-6-methylbenzoic acid; 2,4-Dichloro-3-methyl-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0°C; 1 - 2 h; 2: methanol 16 h; 3: With N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/89897 A1, 2004 ;
Location in patent: Page 19; 20; 26 ;
WO 2004/089897 A1
反应条件
1: 2,4-dichloro benzoic acid With sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; cyclohexane
T=-78 - 25°C; 4 h;
3: With hydrogenchloride; water
more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/89897 A1, 2004 ;
Location in patent: Page 19; 20; 26 ;
WO 2004/089897 A1
参考文献
Claus; Stapelberg
Justus Liebigs Annalen der Chemie, 1893 , vol. 274, p. 291
反应条件
1: durch Austausch von NH2 gegen CN
2: alcoholic KOH-solution
View Scheme
参考文献
Claus; Stapelberg
Justus Liebigs Annalen der Chemie, 1893 , vol. 274, p. 291