(S)-n-苯基乙酰基-beta-苯丙氨酸合成路线 （共 8 条）
反应条件
penicillin G acylase; Eupergit in ethanol; water
4 h; Ambient temperature;
参考文献
Cardillo; Gentilucci; Tolomelli; Tomasini
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2351 - 2353
反应条件
1: 75 percent / H2O; acetone
2: 35 percent / NaHCO3 / penicillin acylase / H2O
View Scheme
参考文献
Leflemme, Nicolas; Dallemagne, Patrick; Rault, Sylvain
Tetrahedron Letters, 2001 , vol. 42, # 51 p. 8997 - 8999
反应条件
sodium hydrogencarbonate; penicillin acylase in water
Soloshonok procedure;
参考文献
Leflemme, Nicolas; Dallemagne, Patrick; Rault, Sylvain
Tetrahedron Letters, 2001 , vol. 42, # 51 p. 8997 - 8999
反应条件
1: 75 percent / H2O; acetone
2: 35 percent / NaHCO3 / penicillin acylase / H2O
View Scheme
参考文献
Leflemme, Nicolas; Dallemagne, Patrick; Rault, Sylvain
Tetrahedron Letters, 2001 , vol. 42, # 51 p. 8997 - 8999
反应条件
1: 75 percent / ammonium acetate / ethanol / 6 h / Heating
2: 75 percent / Et3N / acetone; H2O / 1.) -5 deg C, 2 h, 2.) room temp., 3 h
3: 100 percent / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature
View Scheme
参考文献
Cardillo; Gentilucci; Tolomelli; Tomasini
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2351 - 2353
反应条件
water
Enzymatic reaction;
参考文献
Grayson, J. Ian; Roos, Juergen; Osswald, Steffen
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1201 - 1206
反应条件
1.1: thionyl chloride / 2 h / |Reflux
1.2: |Reflux
2.1: Methylobacterium sp. Y1-6 / 16 h / 30 °C
View Scheme
参考文献
Li, Yi; Wang, Wenfu; Huang, Yumian; Zou, Qianwen; Zheng, Guojun
Process Biochemistry, 2013 , vol. 48, # 11 p. 1674 - 1678
参考文献
Soloshonok; Fokina; Rybakova; Shishkina; Galushko; Sorochinsky; Kukhar; Savchenko; Svedas
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1601 - 1610
