2-氧代-2,3-二氢-苯并噁唑-5-羧酸合成路线 (共 4 条)
反应条件
1: 3-amino-4-hydroxy benzoic acid With sodium carbonate in water T=45°C; 2: methyl chloroformate in water T=45 - 80°C; 3: With hydrogenchloride in water pH=2 - 3; Cooling with ice;
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
Location in patent: Page/Page column 8 ;
参考文献
Journal of the American Chemical Society, , vol. 80, p. 1662
参考文献
Journal of the American Chemical Society, , vol. 75, p. 2770
反应条件
potassium hydroxide in ethanol 4 h; Ambient temperature;
参考文献
Mincheva; Kalcheva; Golovinsky; Tabakova
Pharmazie, 1993 , vol. 48, # 11 p. 859 - 860