反应条件
1: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature 2: 0.75 g / Et3N / acetone / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 3: SOCl2 / Ambient temperature 4: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 5: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Cardillo; Gentilucci; Tolomelli; Tomasini
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2351 - 2353
