3-苄基-6-溴-2-氯喹啉合成路线 （共 12 条）
反应条件
1: With thiourea in ethanol
8 h; Heating / reflux;
2: With potassium hydroxide; ethanol; water
T=20°C; 1 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/435 A1, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
1: diethylene glycol monoethyl ether With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: 3-benzyl-6-bromo-2-chloro-quinoline in tetrahydrofuran
T=0°C; 18 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/436 A1, 2007 ;
Location in patent: Page/Page column 42 ;
