[(1R,3R,4S,6S)-4-氨基-4,7,7-三甲基双环[4.1.0]庚-3-基]甲醇合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 2 h;
参考文献
Gyonfalvi, Szilvia; Szakonyi, Zsolt; Fueloep, Ferenc
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3965 - 3972
反应条件
1: 76 percent / diethyl ether / 9 h / 20 °C
2: 82 percent / Et3N; DMAP / tetrahydrofuran / 2 h / 20 °C
3: 89 percent / NaOMe / 2 h / 20 °C
4: 96 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 0 °C
5: 85 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Gyonfalvi, Szilvia; Szakonyi, Zsolt; Fueloep, Ferenc
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3965 - 3972
反应条件
1: 82 percent / Et3N; DMAP / tetrahydrofuran / 2 h / 20 °C
2: 89 percent / NaOMe / 2 h / 20 °C
3: 96 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 0 °C
4: 85 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Gyonfalvi, Szilvia; Szakonyi, Zsolt; Fueloep, Ferenc
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3965 - 3972
反应条件
1: 89 percent / NaOMe / 2 h / 20 °C
2: 96 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 0 °C
3: 85 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Gyonfalvi, Szilvia; Szakonyi, Zsolt; Fueloep, Ferenc
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3965 - 3972
反应条件
1: 96 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 0 °C
2: 85 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Gyonfalvi, Szilvia; Szakonyi, Zsolt; Fueloep, Ferenc
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3965 - 3972
反应条件
1: 98 percent / diethyl ether / 1 h / 20 °C
2: 96 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 0 °C
3: 85 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Gyonfalvi, Szilvia; Szakonyi, Zsolt; Fueloep, Ferenc
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3965 - 3972
