N-甲基-1-萘甲胺盐酸盐合成路线 （共 16 条）
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in benzene below 60 deg C;
参考文献
Stanetty; Wallner
Archiv der Pharmazie, 1993 , vol. 326, # 6 p. 341 - 350
反应条件
potassium hydroxide in polyethylene glycol-400 (PEG-400) T=25 - 40°C; 5 h;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2006/84826 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
sodium hydroxide; sodium borohydride in isopropyl alcohol; toluene
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
sodium carbonate in water T=10 - 75°C; 6.75 h; Product distribution / selectivity;
参考文献
SATYANARAYANA REDDY, Manne; RAMA SUBBA REDDY, Karamala
Patent: WO2007/96904 A2, 2007 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: 1.) nBuLi, 2.) nBuLi / 1.) 0 deg C, THF, 2.) from -78 deg C to 23 deg C 2: 1.) Cp2ZrHCl, 2.) I2 / 1.) 23 deg C, benzene, 17 h 3: 87 percent / bis(acetonitrile) palladium dichloride / dimethylformamide / 1 h / 0 °C View Scheme
参考文献
Rudisill; Castonguay; Stille
Tetrahedron Letters, 1988 , vol. 29, # 13 p. 1509 - 1512
反应条件
n-butyllithium 1.) 0 deg C, THF, 2.) from -78 deg C to 23 deg C; Yield given. Multistep reaction;
参考文献
Rudisill; Castonguay; Stille
Tetrahedron Letters, 1988 , vol. 29, # 13 p. 1509 - 1512
反应条件
sodium hydroxide; sodium borohydride in ethyl acetate; isopropyl alcohol; toluene
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
sodium hydroxide; sodium borohydride; acetic acid in ethyl acetate; toluene; tert-butyl alcohol
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
sodium hydroxide; sodium borohydride in ethyl acetate; isopropyl alcohol; toluene
参考文献
Lee, Tai-Au; Wang, Kyu-Jung; Kim, Hong-Bae; Kwon, Kyoung-Chan; Ku, Chang-Hoe
Patent: US2003/130530 A1, 2003 ;
反应条件
1: With potassium carbonate in dimethyl sulfoxide T=25 - 60°C; 4.25 - 6.5 h; 2: With hydrogenchloride in water; ethyl acetate T=0 - 10°C; pH=1.5 - 2; 0.5 h; Product distribution / selectivity;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2006/84826 A1, 2006 ;
Location in patent: Page/Page column 4 ;
