1-苄基-1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮合成路线 （共 12 条）
反应条件
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=100°C; 240 h; Inert atmosphere;
参考文献
Cropper, Emma L.; Yuen, Aui-Ping; Ford, Agnes; White, Andrew J.P.; (Mimi) Hii, King Kuok
Tetrahedron, 2009 , vol. 65, # 2 p. 525 - 530
反应条件
1: 66 percent / chromium trioxide, 1.5M sulfuric acid / acetone / 4 h / 0 °C
2: thionyl chloride / 2.5 h / Ambient temperature
3: CH2Cl2 / 0.25 h / 0 °C
4: 5 percent / K2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(o-tolyl)phosphine / toluene / 25 h / 110 °C
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: thionyl chloride / 2.5 h / Ambient temperature
2: CH2Cl2 / 0.25 h / 0 °C
3: 5 percent / K2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(o-tolyl)phosphine / toluene / 25 h / 110 °C
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: CH2Cl2 / 0.25 h / 0 °C
2: 5 percent / K2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(o-tolyl)phosphine / toluene / 25 h / 110 °C
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 73 percent / 9-BBN, 6M NaOH, 30percent H2O2 / 1.5 h / 50 °C
2: 66 percent / chromium trioxide, 1.5M sulfuric acid / acetone / 4 h / 0 °C
3: thionyl chloride / 2.5 h / Ambient temperature
4: CH2Cl2 / 0.25 h / 0 °C
5: 5 percent / K2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(o-tolyl)phosphine / toluene / 25 h / 110 °C
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 96 percent / tetrahydrofuran; diethyl ether / 1.5 h / Heating
2: 73 percent / 9-BBN, 6M NaOH, 30percent H2O2 / 1.5 h / 50 °C
3: 66 percent / chromium trioxide, 1.5M sulfuric acid / acetone / 4 h / 0 °C
4: thionyl chloride / 2.5 h / Ambient temperature
5: CH2Cl2 / 0.25 h / 0 °C
6: 5 percent / K2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(o-tolyl)phosphine / toluene / 25 h / 110 °C
View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 2a. NaH / 1. ether, RT, 2 h, 2a. THF, 0 deg C, 2b. RT overnight
2: Bu3SnCl, NaBH3CN / 2-methyl-propan-2-ol / 12 h / Heating
View Scheme
参考文献
Clark; Jones; McCarthy; Storey
Tetrahedron Letters, 1991 , vol. 32, # 24 p. 2829 - 2832
反应条件
1: 2a. NaH / 1. ether, RT, 2 h, 2a. THF, 0 deg C, 2b. RT overnight
2: Bu3SnCl, NaBH3CN / 2-methyl-propan-2-ol / 12 h / Heating
View Scheme
参考文献
Clark; Jones; McCarthy; Storey
Tetrahedron Letters, 1991 , vol. 32, # 24 p. 2829 - 2832
反应条件
sodium hydride in N,N-dimethyl-formamide
3 h;
参考文献
Johnson, Graham P.; Marples, Brian A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3399 - 3406
反应条件
tributyltin chloride; sodium cyanoborohydride in tert-butyl alcohol
12 h; Heating;
参考文献
Clark; Jones; McCarthy; Storey
Tetrahedron Letters, 1991 , vol. 32, # 24 p. 2829 - 2832
