1: dimethylformaldehyde dimethyl acetal With acetyl chloride; zinc dibromide in dichloromethane T=20 - 30°C; 3.5 h; 2: 2',4',6'-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine in dichloromethane T=5 - 10°C;

N-ethyl-N,N-diisopropylamine in dichloromethane T=3°C; 3 h; Inert atmosphere;

暂无反应条件数据

sodium hydroxide; tetrabutyl-ammonium chloride 1.) CH2Cl2, water, RT, 15 min, 2.) CH2Cl2, water, RT, 16 h; Yield given. Multistep reaction;

1: potassium hydroxide / ethanol 2: hydrogenchloride / methanol; water / 0.5 h / Reflux View Scheme

1: 44 percent / KOH / ethanol / 75 h / 20 °C 2: 40 percent / 3N aq. HCl / methanol / 0.25 h / Heating 3: 40 percent / H2; AcOH / 5 percent Pd/C / 4 h / 20 °C View Scheme

1: 0.45 g / KOH / methanol / 20 h / 20 °C 2: KOH / ethanol / 3 h / 20 °C 3: 0.32 g / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / dioxane / 3 h / Heating 4: 0.45 g / aq. HCl / methanol / 0.25 h / Heating View Scheme

1: potassium hydroxide / ethanol 2: hydrogenchloride / methanol; water / 0.5 h / Reflux View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 1 h / |Reflux 3.1: potassium carbonate / acetone / 0.17 h 3.2: 2 h / 50 °C 4.1: copper dichloride; chloro-trimethyl-silane / acetonitrile / 0.5 h / 20 °C 5.1: Lindlar's catalyst; ammonium formate / methanol; ethyl acetate / 0.67 h / 50 °C 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 7.1: hydrogenchloride; water / tetrahydrofuran / 5 h / |Reflux 8.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 0.17 h / 20 °C / |Inert atmosphere 9.1: sodium acetate / acetic anhydride / 6 h / 170 °C / |Microwave irradiation 9.2: 0.5 h / 20 °C View Scheme

1: potassium hydroxide / ethanol 2: hydrogenchloride / methanol; water / 0.5 h / Reflux View Scheme