1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 5 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: chloroformic acid ethyl ester; potassium carbonate / tetrahydrofuran / 24 h / -78 - 20 °C / Inert atmosphere 3.1: sodium tetrahydroborate / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 5 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: chloroformic acid ethyl ester; potassium carbonate / tetrahydrofuran / 24 h / -78 - 20 °C / Inert atmosphere 3.1: sodium tetrahydroborate / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme

hydrogenchloride; ammonium cerium(IV) nitrate; water 1.) acetonitrile, RT, 2h; Yield given. Multistep reaction;

暂无反应条件数据

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 5 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: chloroformic acid ethyl ester; potassium carbonate / tetrahydrofuran / 24 h / -78 - 20 °C / Inert atmosphere 3.1: sodium tetrahydroborate / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme

1: 1) n-BuLi / 1) ether, 0 deg C, 1 h; 2) 8 h 2: ethyl chloroformate, NaHCO3 / benzene / 0.25 h 3: dimethylformamide / 20 h 4: 1) KOH; 2) HCl / 1) methanol, water, reflux, 1.5 h; 2) water, 2 h 5: 70 percent / ethanol / 4.5 h / Ambient temperature 6: 1) PCl5; 2) NaBH4 / 1) CHCl3, room t., 20 min; 2) MeOH, 1.5 h View Scheme

暂无反应条件数据

Yield given. Multistep reaction;

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 5 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: chloroformic acid ethyl ester; potassium carbonate / tetrahydrofuran / 24 h / -78 - 20 °C / Inert atmosphere 3.1: sodium tetrahydroborate / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme

T=170 - 190°C; anschliessenden Hydrolysieren;