1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 5 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: chloroformic acid ethyl ester; potassium carbonate / tetrahydrofuran / 24 h / -78 - 20 °C / Inert atmosphere 3.1: sodium tetrahydroborate / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 4.2: -78 - 20 °C / Inert atmosphere 5.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere 6.1: trifluoroacetic acid / toluene / 0.5 h / 140 °C / Microwave irradiation 6.2: pH 8 View Scheme

T=170 - 190°C; anschliessenden Hydrolysieren;

1: 1) n-BuLi / 1) ether, 0 deg C, 1 h; 2) 8 h 2: ethyl chloroformate, NaHCO3 / benzene / 0.25 h 3: dimethylformamide / 20 h 4: 1) KOH; 2) HCl / 1) methanol, water, reflux, 1.5 h; 2) water, 2 h View Scheme

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