3′-溴-2,2,2-三氟苯乙酮合成路线 （共 10 条）
反应条件
tetrabutyl ammonium fluoride in toluene T=-78 - 20°C;
参考文献
3-DIMENSIONAL PHARMACEUTICALS, INC.
Patent: WO2003/99805 A1, 2003 ;
Location in patent: Page 118 ;
反应条件
sulfuric acid; dibromoisocyanuric acid 10 deg C to RT;
参考文献
Kogon, Alexander A.; Bochkariov, Dmitry E.; Baskunov, Boris P.; Cheprakov, Andrew V.
Liebigs Annalen der Chemie, 1992 , # 8 p. 879 - 882
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 22 h; Reflux;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1.1: cesium fluoride / toluene / 0.17 h / 0 °C 1.2: 24 h / 0 - 20 °C 2.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: pyridine / dichloromethane / 0 - 20 °C 2.1: cesium fluoride / toluene / 0.17 h / 0 °C 2.2: 24 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 4 h / |Acidic conditions 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 22 h / |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 33 p. 4483 - 4486
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 4 p. 1129 - 1137
反应条件
potassium hydroxide; hydroxylamine hydrochloride in isopropyl alcohol
48 h; Heating;
参考文献
Kogon, Alexander A.; Bochkariov, Dmitry E.; Baskunov, Boris P.; Cheprakov, Andrew V.
Liebigs Annalen der Chemie, 1992 , # 8 p. 879 - 882
反应条件
lithium aluminium tetrahydride
参考文献
Norcross, Bruce E.; Lewis, William C.; Gai, Huiffa; Noureldin, Nazih A.; Lee, Donald G.
Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 129 - 139
反应条件
triphenylphosphine in various solvent(s)
T=70°C;
参考文献
Burton, Donald J.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 339 - 358
