2,2,2,4'-四氟苯乙酮合成路线 （共 25 条）
反应条件
1: AlCl3 2: K2CO3 View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , p. 591 - 595
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 3 p. 614 - 618
反应条件
magnesium ester of trifluoroacetic acid as aduct; Multistep reaction;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 317 - 324
Zhurnal Organicheskoi Khimii, , vol. 18, # 2 p. 365 - 373
反应条件
[2,2']bipyridinyl; N,N-dimethyl acetamide; copper in various solvent(s) T=60°C; 77 h; further reagents, solvents, temperatures, times; Product distributionMechanism;
参考文献
Journal of Fluorine Chemistry, , vol. 65, # 1-2 p. 59 - 66
反应条件
1: Et3N / dimethylsulfoxide / 0.5 h 2: aq. NaOH / dimethylformamide / 2 h View Scheme
参考文献
Shinozuka, Tsuyoshi; Nakao, Akira; Saito, Keiji; Naito, Satoru
Chemistry Letters, 2006 , vol. 35, # 10 p. 1090 - 1091
反应条件
triphenylphosphine in diethylene glycol dimethyl ether
参考文献
Herkes,F.E.; Burton,D.J.
Journal of Organic Chemistry, 1967 , vol. 32, p. 1311 - 1318
反应条件
1: dibromo-difluoro-methane With triphenylphosphine in N,N-dimethyl-formamide 2: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone in N,N-dimethyl-formamide Wittig reaction;
参考文献
Bhadury, Pinaki S.; Palit, Meehir; Sharma, Mamta; Raza, Syed K.; Jaiswal, Devendra K.
Journal of Fluorine Chemistry, 2002 , vol. 116, # 1 p. 75 - 80
反应条件
ammonia in dimethyl sulfoxide
参考文献
Mertz, Eric; Zimmerman, Steven C.
Journal of the American Chemical Society, 2003 , vol. 125, # 12 p. 3424 - 3425
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone in tetrahydrofuran; diethyl ether T=20°C; 2 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
1: Et3N / dimethylsulfoxide / 0.5 h 2: aq. NaOH / dimethylformamide / 2 h View Scheme
参考文献
Shinozuka, Tsuyoshi; Nakao, Akira; Saito, Keiji; Naito, Satoru
Chemistry Letters, 2006 , vol. 35, # 10 p. 1090 - 1091
反应条件
hydrazine in dimethyl sulfoxide T=90°C; 1 h;
参考文献
Tschirret-Guth, Richard A.; Medzihradszky, Katalin F.; Ortiz De Montellano, Paul R.
Journal of the American Chemical Society, 1999 , vol. 121, # 20 p. 4731 - 4737
