2,6-二氯吡啶-3-羧酸甲酯合成路线 （共 22 条）
反应条件
thionyl chloride Heating / reflux;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/14168 A1, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/014168 A1
反应条件
potassium carbonate in acetone T=20°C; 16 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2062901 A1, 2009 ;
Location in patent: Page/Page column 2 ;
反应条件
in dichloromethane; N,N-dimethyl-formamide T=20°C;
参考文献
MERIAL LIMITED; LE HIR DE FALOIS, Loic, Patrick; LEE, Hyoung, Lk; WILKINSON, Douglas, Edward; BECK, Brent, Christopher
Patent: WO2011/75591 A1, 2011 ;
Location in patent: Page/Page column 90 ;
反应条件
hydrogenchloride in methanol
参考文献
Kawato, Toshio; Newkome, George R.
Heterocycles, 1990 , vol. 31, # 6 p. 1097 - 1104
反应条件
in n-heptane; benzene
参考文献
WO2007/18956 A2, ;
Page/Page column 24-25 ;
反应条件
in methanol; n-heptane; benzene Product distribution / selectivity;
参考文献
WO2006/96564 A1, ;
Page/Page column 51 ;
WO 2006/096564 A1
反应条件
1.1: t-BuOK / dimethylformamide / 0.25 h / 20 °C 1.2: dimethylformamide / 1 h / -30 °C 1.3: 87 percent / NaOMe / tetrahydrofuran / 2 h / Heating 2.1: 89 percent / 60 percent MCPBA / CH2Cl2 / 0.75 h / 20 °C 3.1: 90 percent / ethanol; dimethylformamide / 1 h / 60 °C 4.1: 96 percent / NBS / dimethylformamide / 4 h / 80 °C View Scheme
参考文献
Hirokawa; Horikawa; Kato
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1847 - 1853
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 16 h; Heating / reflux;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2062901 A1, 2009 ;
Location in patent: Page/Page column 22-23 ;
反应条件
potassium carbonate; PXPd2 in methanol 0.5 h; Heating;
参考文献
Yang, Wu; Wang, Yufeng; Corte, James R.
Organic Letters, 2003 , vol. 5, # 17 p. 3131 - 3134
