2,6-二氯吡啶-3-羧酸甲酯合成路线 （共 22 条）
反应条件
in dichloromethane T=0°C;
参考文献
PFIZER INC.; ARHANCET, Graciela Barbieri; CASIMIRO-GARCIA, Agustin; CHEN, Xiangyang; HEPWORTH, David; MEYERS, Marvin Jay; PIOTROWSKI, David Walter; RAHEJA, Raj Kumar
Patent: WO2010/116282 A1, 2010 ;
Location in patent: Page/Page column 66 ;
WO 2010/116282 A1
反应条件
1.1: t-BuOK / dimethylformamide / 0.25 h / 20 °C
1.2: dimethylformamide / 1 h / -30 °C
1.3: 87 percent / NaOMe / tetrahydrofuran / 2 h / Heating
2.1: 89 percent / 60 percent MCPBA / CH2Cl2 / 0.75 h / 20 °C
3.1: 90 percent / ethanol; dimethylformamide / 1 h / 60 °C
4.1: 96 percent / NBS / dimethylformamide / 4 h / 80 °C
5.1: 100 percent / aq. NaOH / methanol / 1.5 h / Heating
View Scheme
参考文献
Hirokawa; Horikawa; Kato
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1847 - 1853
