1,2,3,4-四氢异喹啉-1-硫酮合成路线 （共 12 条）
反应条件
1: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature 2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C 3: 93 percent / H2 / 10percent Pd/C / methanol View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
potassium hydroxide; dihydrogen peroxide in methanol; water 0.5 h; Ambient temperature;
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature 2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
tetraphosphorus decasulfide in dichloromethane
5 h; Inert atmosphereReflux;
参考文献
Cho, Dongho; Ahn, Jiyoung; De Castro, Kathlia A.; Ahn, Hyunseok; Rhee, Hakjune
Tetrahedron, 2010 , vol. 66, # 30 p. 5583 - 5588
反应条件
PPA
T=145°C; 0.25 h;
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: acetic acid; hydrogen / Pd/C / 20 h / 20 °C
2: 0.47 g / Lawesson's reagent / tetrahydrofuran / 60 h / 50 °C
View Scheme
参考文献
Cai, Cuiman; Plummer, Janet S.; Connor, David; Holsworth, Daniel D.; Edmunds, Jeremy J.
Synthetic Communications, 2005 , vol. 35, # 3 p. 349 - 356
反应条件
sulfur in pyridine
6 h; Heating; Mechanism;
参考文献
Ajzert, Ilona K.; Takacs, Kalman
Liebigs Annalen der Chemie, 1987 , p. 1061 - 1064
反应条件
1: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature
2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
3: 93 percent / H2 / 10percent Pd/C / methanol
4: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature
2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
3: 93 percent / H2 / 10percent Pd/C / methanol
4: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
5: 60 percent / conc. HCl / 30 h / 150 °C / 31028.9 Torr
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 94 percent / KOH, H2O2 / H2O; methanol / 0.5 h / Ambient temperature
2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
3: 93 percent / H2 / 10percent Pd/C / methanol
4: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
5: 60 percent / conc. HCl / 30 h / 150 °C / 31028.9 Torr
6: 84 percent / NaOAc / H2O; acetic acid / 1 h / 50 °C
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
