4-氯-5-氟喹啉-3-羧酸乙酯合成路线 （共 6 条）
反应条件
trichlorophosphate
T=90°C; 0.833333 h;
参考文献
Carotti, Andrea; Altomare, Cosimo; Savini, Luisa; Chiasserini, Luisa; Pellerano, Cesare; Mascia, Maria P.; Maciocco, Elisabetta; Busonero, Fabio; Mameli, Manuel; Biggio, Giovanni; Sanna, Enrico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5259 - 5272
反应条件
1.1: HCl; aq. NaNO2 / 0 °C
1.2: CuBr; HCl / 0 - 60 °C
2.1: H2 / Raney Ni
3.1: 95 percent / 16 h / Heating
4.1: 79 percent / diphenyl ether / 1 h / Heating
5.1: 92 percent / AcONa; H2 / Pd/C / acetic acid / 10 h / 20 °C / 1810.02 Torr
6.1: 58 percent / POCl3 / 0.83 h / 90 °C
View Scheme
参考文献
Carotti, Andrea; Altomare, Cosimo; Savini, Luisa; Chiasserini, Luisa; Pellerano, Cesare; Mascia, Maria P.; Maciocco, Elisabetta; Busonero, Fabio; Mameli, Manuel; Biggio, Giovanni; Sanna, Enrico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5259 - 5272
反应条件
1: H2 / Raney Ni
2: 95 percent / 16 h / Heating
3: 79 percent / diphenyl ether / 1 h / Heating
4: 92 percent / AcONa; H2 / Pd/C / acetic acid / 10 h / 20 °C / 1810.02 Torr
5: 58 percent / POCl3 / 0.83 h / 90 °C
View Scheme
参考文献
Carotti, Andrea; Altomare, Cosimo; Savini, Luisa; Chiasserini, Luisa; Pellerano, Cesare; Mascia, Maria P.; Maciocco, Elisabetta; Busonero, Fabio; Mameli, Manuel; Biggio, Giovanni; Sanna, Enrico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5259 - 5272
反应条件
1: 95 percent / 16 h / Heating
2: 79 percent / diphenyl ether / 1 h / Heating
3: 92 percent / AcONa; H2 / Pd/C / acetic acid / 10 h / 20 °C / 1810.02 Torr
4: 58 percent / POCl3 / 0.83 h / 90 °C
View Scheme
参考文献
Carotti, Andrea; Altomare, Cosimo; Savini, Luisa; Chiasserini, Luisa; Pellerano, Cesare; Mascia, Maria P.; Maciocco, Elisabetta; Busonero, Fabio; Mameli, Manuel; Biggio, Giovanni; Sanna, Enrico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5259 - 5272
反应条件
1: 92 percent / AcONa; H2 / Pd/C / acetic acid / 10 h / 20 °C / 1810.02 Torr
2: 58 percent / POCl3 / 0.83 h / 90 °C
View Scheme
参考文献
Carotti, Andrea; Altomare, Cosimo; Savini, Luisa; Chiasserini, Luisa; Pellerano, Cesare; Mascia, Maria P.; Maciocco, Elisabetta; Busonero, Fabio; Mameli, Manuel; Biggio, Giovanni; Sanna, Enrico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5259 - 5272
反应条件
1: 79 percent / diphenyl ether / 1 h / Heating
2: 92 percent / AcONa; H2 / Pd/C / acetic acid / 10 h / 20 °C / 1810.02 Torr
3: 58 percent / POCl3 / 0.83 h / 90 °C
View Scheme
参考文献
Carotti, Andrea; Altomare, Cosimo; Savini, Luisa; Chiasserini, Luisa; Pellerano, Cesare; Mascia, Maria P.; Maciocco, Elisabetta; Busonero, Fabio; Mameli, Manuel; Biggio, Giovanni; Sanna, Enrico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5259 - 5272
