2,4-二氯-6-乙基嘧啶合成路线 （共 7 条）
反应条件
1: red phosphorus; HI 2: POCl3 View Scheme
参考文献
Caldwell; Ziegler
Journal of the American Chemical Society, 1936 , vol. 58, p. 78
反应条件
1: red phosphorus; HI 2: POCl3 3: ethanol; NH3 View Scheme
参考文献
Caldwell; Ziegler
Journal of the American Chemical Society, 1936 , vol. 58, p. 78
反应条件
hydrogenchloride; water 2 h; Reflux;
参考文献
Boehringer Ingelheim International GmbH; EICKMEIER, Christian; GERLACH, Kai; HEINE, Niklas; WEBER, Alexander; GROSS, Ulrike
Patent: US2013/225593 A1, 2013 ;
Location in patent: Paragraph 0398 ;
反应条件
1: 2,4,6-trichloro-pyrimidine With copper(l) iodide in tetrahydrofuran
Inert atmosphere;
2: ethylmagnesium bromide in tetrahydrofuran
T=0 - 20°C; 14 h;
参考文献
Boehringer Ingelheim International GmbH; GERLACH, Kai; EICKMEIER, Christian; HEINE, Claudia; HEINE, Niklas; WEBER, Alexander
Patent: US2013/225549 A1, 2013 ;
Location in patent: Paragraph 0381 ;
反应条件
1: 2,4-dichloro-6-methyl-pyrimidine With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.583333 h;
2: methyl iodide in tetrahydrofuran
T=-78°C; 3 h;
参考文献
Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 29 ;
US 20040087601 A1
反应条件
sodium methylate; thiourea in ethanol
参考文献
Yuhan Corporation
Patent: US5750531 A1, 1998 ;
参考文献
Caldwell; Ziegler
Journal of the American Chemical Society, 1936 , vol. 58, p. 78
