6-甲基水杨酸乙酯/2-羟基-6-甲基苯甲酸乙酯合成路线 （共 27 条）
反应条件
1: K2CO3 / acetone / 12 h / Heating 2: 10percent aq. NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Hauser, Frank M.; Pogany, Stefano A.
Synthesis, 1980 , # 10 p. 814 - 815
反应条件
1: K2CO3 / acetone 2: 1.) LDA, 2.) HMPA / 1.) THF, -70 deg C, 10 min, 2.) THF, -70 deg 3: 72 percent / tBuSLi / 7 h / Heating View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 228 - 240
反应条件
3: 95 percent
4: 96 percent
View Scheme
参考文献
Matsuda, Fuyuhiko; Kawasaki, Motoji; Ohsaki, Masako; Yamada, Kaoru; Terashima, Shiro
Tetrahedron, 1988 , vol. 44, # 18 p. 5745 - 5760
反应条件
1: K2CO3 / acetone / 12 h / Heating
2: 10percent aq. NaOH / ethanol / 24 h / Heating
3: (COCl)2 / benzene / Ambient temperature
View Scheme
参考文献
Chatterjea, J. N.; Singh, K. R. R. P.; Jha, I. S.; Prasad, Y.; Shaw, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 796 - 798
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 57 ;
反应条件
methylmagnesium bromide; triethylamine in diethyl ether; toluene
T=0 - 20°C; 16 h;
参考文献
LABORATOIRE BIODIM; CHASSET, Sophie; CHEVREUIL, Francis; LEDOUSSAL, Benoit; LE STRAT, Frederic; BENAROUS, Richard
Patent: WO2012/137181 A1, 2012 ;
Location in patent: Page/Page column 119 ;
反应条件
triethylamine in toluene
T=0 - 20°C;
参考文献
Uto, Yoshikazu; Ueno, Yuko; Kiyotsuka, Yohei; Miyazawa, Yuriko; Kurata, Hitoshi; Ogata, Tsuneaki; Yamada, Makiko; Deguchi, Tsuneo; Konishi, Masahiro; Takagi, Toshiyuki; Wakimoto, Satoko; Ohsumi, Jun
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 4788 - 4796
