2-溴-5-碘-3-甲基吡啶合成路线 （共 5 条）
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 1 h; 2: With iodine in tetrahydrofuran T=20°C; 24 h;
参考文献
Katritzky, Alan R.; Tala, Srinivasa R.; Lu, Hong; Vakulenko, Anatoliy V.; Chen, Qi-Yin; Sivapackiam, Jothilingam; Pandya, Keyur; Jiang, Shibo; Debnath, Asim K.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7631 - 7639
反应条件
hydrogen bromide; bromine; sodium nitrite T=0°C; 0.5 h;
参考文献
Hsieh; McLaughlin
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5356 - 5359
反应条件
1: 73 percent / HIO4*2H2O, I2, H2SO4 / aq. acetic acid / 4 h / 80 °C 2: 94 percent / 48percent HBr, Br2, aq. NaNO2 / 0.5 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5356 - 5359
反应条件
sodium methylate in methanol; dimethyl sulfoxide T=0 - 70°C;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: US2004/102450 A1, 2004 ;
Location in patent: Page/Page column 75 ;
反应条件
potassium permanganate in water
48 h; Reflux;
参考文献
Katritzky, Alan R.; Tala, Srinivasa R.; Lu, Hong; Vakulenko, Anatoliy V.; Chen, Qi-Yin; Sivapackiam, Jothilingam; Pandya, Keyur; Jiang, Shibo; Debnath, Asim K.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7631 - 7639
