(5E)-5-(2,6-二氯亚苄基)-2-疏基-1,3-噻唑-4(5H)-酮合成路线 （共 4 条）
反应条件
1.1: sodium hydroxide; water / 1.5 h / 20 °C 1.2: 0.5 h / 10 °C / |Cooling with ice 2.1: potassium hydroxide / water / 4 h / |Reflux 2.2: 1 h / 20 °C / pH 1 View Scheme
反应条件
sodium acetate in acetic acid
1 h; Heating;
参考文献
Foye; Tovivich
Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 11 p. 1607 - 1611
反应条件
sodium hydroxide in tetrahydrofuran; acetone
Ambient temperature;
参考文献
Foye; Tovivich
Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 11 p. 1607 - 1611
反应条件
1.1: sodium hydroxide; water / 1.5 h / 20 °C
1.2: 0.5 h / 10 °C / |Cooling with ice
2.1: potassium hydroxide / water / 4 h / |Reflux
2.2: 1 h / 20 °C / pH 1
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 160 - 195 °C
View Scheme
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.; SHINHAMA, Koichi; UTSUMI, Naoto; SOTA, Masahiro; FUJIEDA, Shigeo; OGASAWARA, Shin
Patent: WO2013/15456 A1, 2013 ;
