1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / Inert atmosphere; Reflux 2: caesium carbonate; copper(l) iodide; N,N-dimethylaminoacetic acid / N,N-dimethyl-formamide / 3.5 h / 140 °C / Inert atmosphere View Scheme

1.1: potassium tert-butylate / toluene / 3 h / 20 °C 1.2: 3 h / 20 °C 2.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C 3.1: formic acid; iodine; magnesium / toluene; methanol / 5 h / 20 - 40 °C 3.2: 5 - 10 °C / pH ~ 1 4.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 20 °C 4.2: 6 h / Reflux 4.3: 10 - 15 °C View Scheme

1.1: hydrogenchloride / dichloromethane; water / pH 1.5 1.2: 0.75 h / 0 - 15 °C 2.1: potassium tert-butylate / toluene / 3 h / 20 °C 2.2: 3 h / 20 °C 3.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C 4.1: formic acid; iodine; magnesium / toluene; methanol / 5 h / 20 - 40 °C 4.2: 5 - 10 °C / pH ~ 1 5.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 20 °C 5.2: 6 h / Reflux 5.3: 10 - 15 °C View Scheme

暂无反应条件数据

in ethanol; tert-butyl methyl ether T=0 - 20°C; 2 h; SolventTemperatureTime;

1: 227 mg / N-iodosuccinimide, triflic acid / CH2Cl2 / 1 h / Ambient temperature 2: T2 / 10percent Pd/C / ethanol / 1 h / Ambient temperature 3: toluene / Heating 4: 48percent aq. HBr / 2 h / Heating View Scheme