2,2-二氟-1,3-苯并二恶茂-5-甲醛合成路线 （共 14 条）
反应条件
1: 5-bromo-2,2-difluorobenzo[d][1,3]dioxole With n-butyllithium in tetrahydrofuran 0.166667 h; Cooling with acetone-dry ice; 2: N,N-dimethyl-formamide in tetrahydrofuran T=20°C; 2 h; Cooling with acetone-dry ice; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
US2007/37815 A1, ;
Page/Page column 20 ;
反应条件
bromine trifluoride in CFCl3; chloroform T=0°C; 0.0166667 h;
参考文献
Hagooly, Youlia; Welch, Michael J.; Rozen, Shlomo
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 902 - 905
反应条件
hydrogenchloride in water
反应条件
1: sodium carbonate / water / 2 h / 0 °C 2: bromine trifluoride / CFCl3; chloroform / 0.02 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 3 p. 902 - 905
反应条件
pyridine; piperidine Knoevenagel Condensation; 3 h; Heating / reflux;
参考文献
WO2004/96796 A1, ;
Page 33 ;
WO 2004/096796 A1
反应条件
palladium 10 on activated carbon; hydrogen in methanol
T=70°C; P=750.075 Torr;
参考文献
Liu, Jing; Fitzgerald, Anne E.; Mani, Neelakandha S.
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2469 - 2473
反应条件
palladium 10 on activated carbon; hydrogen in methanol
T=50°C; P=15001.5 Torr;
参考文献
Liu, Jing; Fitzgerald, Anne E.; Mani, Neelakandha S.
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2469 - 2473
反应条件
10 platinum on carbon; hydrogen in methanol
T=50°C; P=760.051 Torr;
参考文献
Liu, Jing; Fitzgerald, Anne E.; Mani, Neelakandha S.
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2469 - 2473
反应条件
piperidine; pyridine
3 h; Heating / reflux;
参考文献
Bossenmaier, Birgit; Friebe, Walter-Gunar; Friess, Thomas; Reiff, Ulrike; Voss, Edgar
Patent: US2005/209290 A1, 2005 ;
Location in patent: Page/Page column 10 ;
反应条件
10 palladium on activated charcoal; hydrogen in ethanol
T=50°C; P=760.051 Torr;
参考文献
Liu, Jing; Fitzgerald, Anne E.; Mani, Neelakandha S.
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2469 - 2473
