2,2-二氟-1,3-苯并二噁茂-5-羧酸合成路线 （共 12 条）
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 15 - 40 °C
1.2: 0.5 h / 40 - 50 °C
2.1: thionyl chloride / 4-(N,N-dimethlyamino)pyridine / tert-butyl methyl ether / 1.5 h / 15 - 30 °C
3.1: dimethyl sulfoxide / 1 h / 30 - 40 °C
4.1: tetra-n-octylammonium bromide; potassium hydroxide / water / 1 h / 70 °C
View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; LOOKER, ADAM; Littler, Benjamin Joseph; Choudhury, Anusuya; Harrison, Cristian; Veluri, Ravikanth; Ryan, Michael P.; Jiang, Licong; Luss-Lusis, Eduard
Patent: US2013/116238 A1, 2013 ;
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 15 - 40 °C
1.2: 0.5 h / 40 - 50 °C
2.1: thionyl chloride / 4-(N,N-dimethlyamino)pyridine / tert-butyl methyl ether / 1.5 h / 15 - 30 °C
View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2012/46330 A1, 2012 ;
US 20120046330 A1
