反应条件
1.1: sodium hydroxide / dichloromethane / 1 h / 20 °C 2.1: lithium tert-butylate / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 3 h / 0 - 20 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C 4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C 5.1: iron; ammonium chloride / water; ethanol / 12 h / |Reflux 5.2: 1 h / 20 °C View Scheme
参考文献
LEGOCHEM BIOSCIENCES, INC.; Cho, Young Lag; Baek, Sung Yoon; Chae, Sang Eun; Kim, Sun Young; Lee, Hong Bum; Lee, Hyang Sook; Oh, Kyuman; Park, Tae Kyo; Woo, Sung Ho; Kim, Yong Zu; Heo, Hye Jin
Patent: US2014/179691 A1, 2014 ;