4-溴-3-氟苯胺合成路线

参考文献

Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; Berven, Bradley; Botero, Adriana; Chaplin, Jason H.; Charman, Susan A.; Chatelain, Eric; Von Geldern, Thomas W.; Kerfoot, Maria; Khong, Andrea; Nguyen, Tien; McManus, Joshua D.; Morizzi, Julia; Ryan, Eileen; Scandale, Ivan; Thompson, R. Andrew; Wang, Sen Z.; White, Karen L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4189 - 4204

656-65-54-溴-3-氟苯胺+

56-81-5甘油

127827-52-56-溴-7-氟喹啉

参考文献

PFIZER INC.
Patent: US2007/265272 A1, 2007 ;
Location in patent: Page/Page column 31-32 ;

656-65-54-溴-3-氟苯胺+

98-95-3硝基苯

127827-52-56-溴-7-氟喹啉+

127827-51-46-溴-5-氟喹啉盐酸盐

参考文献

SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
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US 20120245178 A1

656-65-54-溴-3-氟苯胺+

56-81-5甘油

127827-52-56-溴-7-氟喹啉+

127827-51-46-溴-5-氟喹啉盐酸盐

参考文献

HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: WO2011/79804 A1, 2011 ;
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WO 2011/079804 A1

656-65-54-溴-3-氟苯胺

1185768-18-67-氟喹啉-6-甲醛

参考文献

NOVARTIS AG; DAI, Miao; FU, Xingnian; HE, Feng; JIANG, Lei; LI, Yue; LIANG, Fang; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YAN, Xiaoxia; YU, Zhengtian; ZHANG, Ji, Yue
Patent: WO2011/20861 A1, 2011 ;

656-65-54-溴-3-氟苯胺

121219-03-24-溴-3-氟苯酚

参考文献

Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; Berven, Bradley; Botero, Adriana; Chaplin, Jason H.; Charman, Susan A.; Chatelain, Eric; Von Geldern, Thomas W.; Kerfoot, Maria; Khong, Andrea; Nguyen, Tien; McManus, Joshua D.; Morizzi, Julia; Ryan, Eileen; Scandale, Ivan; Thompson, R. Andrew; Wang, Sen Z.; White, Karen L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4189 - 4204

656-65-54-溴-3-氟苯胺

136434-77-01-溴-2-氟-4-碘苯

参考文献

Gray, G. W.; Hird, M.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1991 , vol. 204, p. 43 - 64

656-65-54-溴-3-氟苯胺

153505-36-34-溴-5-氟-2-硝基苯甲胺

参考文献

ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;

656-65-54-溴-3-氟苯胺

118897-99-75-溴-6-氟吲哚啉-2,3-二酮

参考文献

Yen et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1858,1860

656-65-54-溴-3-氟苯胺

153505-37-44-溴-5-氟-1,2-亚苯基二胺

参考文献

ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;