甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯合成路线

参考文献

NOVARTIS AG
Patent: WO2008/62044 A1, 2008 ;
Location in patent: Page/Page column 13; 14 ;
WO 2008/062044 A1

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

65615-90-9(2S)-3-(4-氨基苯基)-2-[(叔丁氧基羰基)氨基]丙酸甲酯

参考文献

F. HOFFMANN-LA ROCHE AG; GOODNOW Jr., Robert, Alan; HAMILTON, Matthew, Michael; SIDDURI, Achyutharao
Patent: WO2013/110680 A1, 2013 ;
Location in patent: Page/Page column 66; 67 ;

24424-99-5二碳酸二叔丁酯+

17193-40-7(S)-4-硝基苯基丙氨酸甲酯盐酸盐

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

ONCOTHYREON INC.; PETERSON, Scott; PESTANO, Linda; FOWLER, Kerry; VO, Cong, Hung
Patent: WO2012/58325 A1, 2012 ;
Location in patent: Page/Page column 71 ;

33305-77-0BOC-L-4-硝基苯丙氨酸+

74-88-4甲基碘

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

Hoffmann-La Roche Inc.; Chin, Jayne; Goodnow, JR., Robert A.; Hamilton, Matthew Michael; Sidduri, Achyutharao
Patent: US2013/197205 A1, 2013 ;
Location in patent: Paragraph 0190; 0191 ;

33305-77-0BOC-L-4-硝基苯丙氨酸

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

F. HOFFMANN-LA ROCHE AG; GOODNOW Jr., Robert, Alan; HAMILTON, Matthew, Michael; SIDDURI, Achyutharao
Patent: WO2013/110680 A1, 2013 ;
Location in patent: Page/Page column 65; 66 ;

33305-77-0BOC-L-4-硝基苯丙氨酸+

18107-18-1三甲基硅烷化重氮甲烷

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

Dyatkin, Alexey B.; Gong, Yong; Miskowski, Tamara A.; Kimball, Edward S.; Prouty, Stephen M.; Fisher, M. Carolyn; Santulli, Rosemary J.; Schneider, Craig R.; Wallace, Nathaniel H.; Hornby, Pamela J.; Diamond, Craig; Kinney, William A.; Maryanoff, Bruce E.; Damiano, Bruce P.; He, Wei
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6693 - 6702

93267-04-0N-(叔-丁氧基羰基)-3-碘-L-丙氨酸甲酯+

586-78-71-溴-4-硝基苯

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

Ross, Andrew J.; Lang, Hannah L.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 245 - 248

67-56-1甲醇+

24424-99-5二碳酸二叔丁酯+

949-99-54-硝基-L-苯丙氨酸

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

Pharmacia and Upjohn Company; Tanabe Seiyaku Co., Ltd.
Patent: US6685617 B1, 2004 ;
Location in patent: Page/Page column 155-156 ;

33305-77-0BOC-L-4-硝基苯丙氨酸+

74-88-4甲基碘

参考文献

Hoffman-La Roche Inc.
Patent: US6229011 B1, 2001 ;

636-98-64-硝基碘苯+

93267-04-0N-(叔-丁氧基羰基)-3-碘-L-丙氨酸甲酯

65615-89-6甲基N-{[(2-甲基-2-丙基)氧基]羰基}-4-硝基苯丙氨酸酯

参考文献

Ross, Andrew J.; Lang, Hannah L.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 245 - 248