1: With hydrogenchloride; water T=20°C; 96 h; 2: With sodium hydroxide in water T=0°C;

1: With hydrogenchloride in water Cooling; 2: With sodium hydroxide in water

hydrogenchloride in methanol

1.1: ethanol / 20 °C 2.1: anhydrous butyl ether / 1 h / 15 - 32 °C 3.1: hydrogenchloride / isopropyl alcohol / 16 h / 5 - 25 °C 4.1: sodium hydroxide / water; 2-methyl tetrahydrofuran / pH > 12 4.2: 16 h / 65 °C 5.1: hydrogenchloride / water / 1 h / 65 °C / pH 1 5.2: 15 - 25 °C / pH >= 12 View Scheme

1.1: hydrogenchloride / isopropyl alcohol / 16 h / 5 - 25 °C 2.1: sodium hydroxide / water; 2-methyl tetrahydrofuran / pH > 12 2.2: 16 h / 65 °C 3.1: hydrogenchloride / water / 1 h / 65 °C / pH 1 3.2: 15 - 25 °C / pH >= 12 View Scheme

1.1: anhydrous butyl ether / 1 h / 15 - 32 °C 2.1: hydrogenchloride / isopropyl alcohol / 16 h / 5 - 25 °C 3.1: sodium hydroxide / water; 2-methyl tetrahydrofuran / pH > 12 3.2: 16 h / 65 °C 4.1: hydrogenchloride / water / 1 h / 65 °C / pH 1 4.2: 15 - 25 °C / pH >= 12 View Scheme

1.1: anhydrous butyl ether / 1 h / 15 - 32 °C 2.1: hydrogenchloride / isopropyl alcohol / 16 h / 5 - 25 °C 3.1: sodium hydroxide / water; 2-methyl tetrahydrofuran / 45 °C / pH > 12 3.2: 16 h / 65 °C 4.1: hydrogenchloride / water / 1 h / 65 °C / pH 1 View Scheme

1.1: sodium hydroxide / water; 2-methyl tetrahydrofuran / 45 °C / pH > 12 1.2: 16 h / 65 °C 2.1: hydrogenchloride / water / 1 h / 65 °C / pH 1 View Scheme

trimethylsilyl trifluoromethanesulfonate in dichloromethane T=22 - 40°C; 65 h; Inert atmosphere;