8-二甲基氨基-1,4-二氧杂螺[4.5]癸烷-8-甲腈合成路线 （共 5 条）
反应条件
hydrogenchloride in methanol; water
T=20°C; 72 h; Cooling with ice;
参考文献
Gruenenthal GmbH
Patent: US2010/48554 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
hydrogenchloride in methanol; water
T=0 - 20°C; 74 h; Product distribution / selectivity;
参考文献
GRUNENTHAL GMBH
Patent: US2009/156593 A1, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
in methanol; dichloromethane
参考文献
The Upjohn Company
Patent: US4115589 A1, 1978 ;
反应条件
in methanol; water
T=20°C; 65 h;
参考文献
Gruenenthal GmbH
Patent: US2004/214822 A1, 2004 ;
Location in patent: Page 10 ;
US 20040214822 A1
反应条件
in methanol; water
48 h; Ambient temperature;
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
