1,3-dibromo-5,5-dimethyl-hydantoin; sodium methylate in methanol; acetonitrile T=15 - 25°C;

1,3-dibromo-5,5-dimethyl-hydantoin; water in acetonitrile T=25°C; pH=5.0 - 6.5;

1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran; hexane T=-50 - -5°C; 1.5 h; 2: With hydrogenchloride; water in tetrahydrofuran; hexane; tert-butyl methyl ether T=20°C; 0.5 h;

1.1: 88 percent Chromat. / 1,3-dibromo-5,5-dimethylhydantoin; NaOMe / acetonitrile; methanol / 15 - 25 °C 2.1: iPrMgCl 2.2: MgClX 2.3: 30 percent / Pd2(dba)3; tBu3P / tetrahydrofuran / 1 h / 23 °C View Scheme