1-(4-溴苯基)-4-乙基哌嗪合成路线 （共 5 条）
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane 12 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13135 A1, 2004 ;
Location in patent: Page 49 ;
WO 2004/013135 A1
反应条件
bromine in ethanol
T=0 - 20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13135 A1, 2004 ;
Location in patent: Page 48 ;
WO 2004/013135 A1
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
T=20°C; 24 h;
2: With hydrogenchloride in tetrahydrofuran; water
1 h; Heating / reflux;
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: EP1559707 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
potassium phosphate; copper(l) iodide; ethylene glycol in isopropyl alcohol
Heating / reflux;
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP1956009 A1, 2008 ;
Location in patent: Page/Page column 88 ;
反应条件
in 1-methyl-pyrrolidin-2-one
T=200 - 204°C; 0.75 h; microwave irradiation;
参考文献
Xu, Gang; Wang, Yan-Guang
Organic Letters, 2004 , vol. 6, # 6 p. 985 - 987
