(S)-1-苄氧羰基六氢哒嗪-3-羧酸合成路线 （共 15 条）
反应条件
1: 40 percent / NaOH / H2O; toluene / 16 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1734 - 1737
反应条件
1: R-(+)-proline / acetonitrile / 12 h / 0 °C 2: sodium chlorite; aminosulfonic acid / dichloromethane; water / 0 °C / |Large scale 3: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 25 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 17, # 9 p. 1209 - 1213
反应条件
1: R-(+)-proline / acetonitrile / 12 h / 0 °C 2: sodium chlorite; aminosulfonic acid / dichloromethane; water / 0 °C / |Large scale 3: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 25 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 17, # 9 p. 1209 - 1213
反应条件
hydrogenchloride; hydrogen; palladium 1.) MeOH, RT, 1 bar, 4 h, 2.) MeOH, 110 deg C, 14 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 2 p. 223 - 229
反应条件
1: 85 percent / H2SO4 / dioxane 2: aq. NaHCO3 3: 97 percent / H2 / Pd/C / methanol 4: PCl5 / tetrahydrofuran 5: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
