3-硝基-4-吡啶乙酸乙酯合成路线 （共 10 条）
反应条件
trifluoroacetic acid in dichloromethane
2 h; Heating / reflux;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 69-70 ;
反应条件
hydrogenchloride in diethyl ether; ethanol
T=20°C; 72 h;
参考文献
Badland, Matthew; Devillers, Ingrid; Durand, Corinne; Fasquelle, Veronique; Gaudillire, Bernard; Jacobelli, Henry; Manage, Ajith C.; Pevet, Isabelle; Puaud, Jocelyne; Shorter, Anthony J.; Wrigglesworth, Roger
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5292 - 5296
反应条件
potassium tert-butylate in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
RE:VIRAL LTD; COCKERILL, Stuart; PILKINGTON, Christopher; LUMLEY, James; ANGELL, Richard; MATHEWS, Neil
Patent: WO2013/68769 A1, 2013 ;
Location in patent: Page/Page column 20; 21 ;
反应条件
lithium chloride in water; dimethyl sulfoxide
参考文献
SmithKline Beecham Corporation
Patent: US6369086 B1, 2002 ;
US 6369086 B1
反应条件
in xylene
96 h; Heating;
参考文献
Duffy, Kevin J.; Tennant, George
Journal of the Chemical Society, Chemical Communications, 1995 , # 23 p. 2457 - 2460
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Large scale reaction
1.2: 1.5 h / Large scale reaction
2.1: hydrogenchloride / diethyl ether; ethanol / 72 h / 20 °C
View Scheme
参考文献
Badland, Matthew; Devillers, Ingrid; Durand, Corinne; Fasquelle, Veronique; Gaudillire, Bernard; Jacobelli, Henry; Manage, Ajith C.; Pevet, Isabelle; Puaud, Jocelyne; Shorter, Anthony J.; Wrigglesworth, Roger
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5292 - 5296
反应条件
1.1: sulfuric acid; nitric acid / 3 h / 60 - 70 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide; trichlorophosphate / toluene / 2 h / Inert atmosphere; Reflux
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Large scale reaction
3.2: 1.5 h / Large scale reaction
4.1: hydrogenchloride / diethyl ether; ethanol / 72 h / 20 °C
View Scheme
参考文献
Badland, Matthew; Devillers, Ingrid; Durand, Corinne; Fasquelle, Veronique; Gaudillire, Bernard; Jacobelli, Henry; Manage, Ajith C.; Pevet, Isabelle; Puaud, Jocelyne; Shorter, Anthony J.; Wrigglesworth, Roger
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5292 - 5296
反应条件
1.1: N,N-dimethyl-formamide; trichlorophosphate / toluene / 2 h / Inert atmosphere; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / Large scale reaction
2.2: 1.5 h / Large scale reaction
3.1: hydrogenchloride / diethyl ether; ethanol / 72 h / 20 °C
View Scheme
参考文献
Badland, Matthew; Devillers, Ingrid; Durand, Corinne; Fasquelle, Veronique; Gaudillire, Bernard; Jacobelli, Henry; Manage, Ajith C.; Pevet, Isabelle; Puaud, Jocelyne; Shorter, Anthony J.; Wrigglesworth, Roger
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5292 - 5296
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
P=1551.49 Torr; 3 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 70 ;
反应条件
palladium on charcoal in ethanol
参考文献
SmithKline Beecham Corporation
Patent: US6369086 B1, 2002 ;
US 6369086 B1
