1H-苯并咪唑-4-基甲醇合成路线 （共 4 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1.25 h; Inert atmosphere; 2: With water; ammonium chloride T=20°C; 1 h;
参考文献
NOVARTIS AG; BERST, Frederic; FURET, Pascal; MARZINZIK, Andreas
Patent: WO2011/157787 A1, 2011 ;
Location in patent: Page/Page column 71-72 ;
WO 2011/157787 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 2: With methanol in tetrahydrofuran
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2008/51494 A1, 2008 ;
Location in patent: Page/Page column 132 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 18 h; Heating;
参考文献
Deghati, Paymaneh Y. F.; Borghini, Alice; Van Den Nieuwendijk, Adrianus M. C. H.; Dissen-de Groote, Miriam; IJzerman, Adriaan P.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 6 p. 899 - 908
反应条件
pyridine-SO3 complex; N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=20°C;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2008/51494 A1, 2008 ;
Location in patent: Page/Page column 132 ;
