3-(叔丁基)-4-羟基苯甲醛合成路线 （共 8 条）
参考文献
Kesarios, N.; Tochon-Danguy, H. J.; Ackermann, U.; Sachinidis, J.; Lambert, J.; Nerrie, M.; Nice, E.; Scott, A. M.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, p. S119 - S119
反应条件
sodium hydroxide in methanol
T=50°C; Reimer-Tiemann reaction; 4.5 h;
参考文献
Cheng, Xue Qin; Chen, Xingqiang; Hughes, Richard A.; Williams, Spencer J.; Woodman, Owen L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1874 - 1884
反应条件
trichlorophosphate
1.) r.t., 1 h; 2.) 50-60 deg C,5 h;
参考文献
Katsumi; Kondo; Yamashita; Hidaka; Hosoe; Watanabe
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 121 - 129
反应条件
1: With sodium hydroxide; water
2: With chloroform in methanol; water
T=60°C; 4 h;
3: With hydrogenchloride in methanol; chloroform; water
pH=5 - 6;
参考文献
Michel, Fabien; Thomas, Fabrice; Hamman, Sylvain; Philouze, Christian; Saint-Aman, Eric; Pierre, Jean-Louis
European Journal of Inorganic Chemistry, 2006 , # 18 p. 3684 - 3696
反应条件
sodium hydroxide in methanol; chloroform; water
参考文献
ICI Australia Limited
Patent: US4064266 A1, 1977 ;
反应条件
formic acid; triphenylphosphine in chloroform; ethyl acetate; acetone
参考文献
Eli Lilly and Company
Patent: US5441984 A1, 1995 ;
US 5441984 A
参考文献
ICI Australia Limited
Patent: US4064266 A1, 1977 ;
反应条件
hydroxylamine hydrochloride; acetic acid
1 h; Reflux;
参考文献
AUTIFONY THERAPEUTICS LIMITED; ALVARO, Giuseppe; DAMBRUOSO, Paolo; MARASCO, Agostino; TOMMASI, Simona; DECOR, Anne; LARGE, Charles
Patent: WO2012/76877 A1, 2012 ;
Location in patent: Page/Page column 226-227 ;
WO 2012/076877 A1
