3-(5-溴吡啶-2-基)-2-(叔丁氧基羰基)丙酸甲酯合成路线 （共 2 条）
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With iodine; zinc in N,N-dimethyl-formamide
T=20°C; 1 h;
2: 2,5-dibromo-pyridine With bis-triphenylphosphine-palladium(II) chloride
T=68°C; Negishi coupling; 2 h;
参考文献
Wang, Limin; Qu, Wenchao; Lieberman, Brian; Ploessl, Karl; Kung, Hank F.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3482 - 3485
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc in N,N-dimethyl-formamide
T=35 - 90°C; 3 h;
2: 2,5-dibromo-pyridine With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=70°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/60409 A1, 2007 ;
Location in patent: Page/Page column 86 ;
WO 2007/060409 A1
