5-甲基-1,2-苯异噁唑-3-醇合成路线 （共 3 条）
反应条件
triethylamine; trichlorophosphate T=20 - 130°C; 5 h;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2004/55024 A1, 2004 ;
Location in patent: Page/Page column 22-23 ;
WO 2004/055024 A1
反应条件
1: With 1,1'-carbonyldiimidazole in tetrahydrofuran
2 h; Reflux;
2: With hydrogenchloride in tetrahydrofuran; water
pH=1;
参考文献
Bolin, David Robert; Hamilton, Matthew Michael; McDermott, Lee Apostle; Qian, Yimin
Patent: US2011/112158 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
1.1: hydroxylamine / 1,4-dioxane; water / 4.5 h / 20 °C
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Reflux
2.2: pH 1
View Scheme
参考文献
Bolin, David Robert; Hamilton, Matthew Michael; McDermott, Lee Apostle; Qian, Yimin
Patent: US2011/112158 A1, 2011 ;
