7-羟基-4-甲氧基甲基香豆素合成路线 （共 5 条）
反应条件
sulfuric acid
1.5 h; Reflux;
参考文献
Zhou, Xiang; Chen, Ya-Dong; Wang, Tao; Wang, Xiao-Bing; Kong, Ling-Yi
Chemistry and Biodiversity, 2011 , vol. 8, # 6 p. 1052 - 1064
反应条件
1: 66 percent / ZnCl2, HCl / diethyl ether / 2 h
2: 68 percent / 50 percent aq. H2SO4 / 4 h
3: 60 percent / 1.5 h / Heating
View Scheme
参考文献
Xie, Lan; Takeuchi, Yasuo; Cosentino, L. Mark; Lee, Kuo-Hsiung
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2662 - 2672
反应条件
1: hydriodic acid; acetic anhydride; acetic acid / 1 h / 80 °C
2: HCl / 1.5 h / Heating
View Scheme
参考文献
Fall; Santana; Uriarte
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1231 - 1232
反应条件
potassium carbonate in acetone
8 h; Reflux;
参考文献
Shen, Qiong; Shao, Jialiang; Peng, Quan; Zhang, Wanjin; Ma, Lin; Chan, Albert S. C.; Gu, Lianquan
Journal of Medicinal Chemistry, 2010 , vol. 53, # 23 p. 8252 - 8259
反应条件
1: sodium hydride / toluene / 3 h / 105 °C / |Inert atmosphere
2: hydrogen iodide / acetic acid; acetic anhydride / 3.5 h / 120 °C / |Reflux
3: sulfuric acid
View Scheme
参考文献
Andres, Julien; Chauvin, Anne-Sophie
Physical Chemistry Chemical Physics, 2013 , vol. 15, # 38 p. 15981 - 15994
