2-氯-5-(三氟甲基)苯甲酸合成路线 （共 18 条）
反应条件
1: methanol With acetyl chloride T=0°C; 0.166667 h; 2: 2-Chloro-5-(trifluoromethyl)benzoic acid T=0°C; 2.5 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/136442 A1, 2006 ;
Location in patent: Page/Page column 90 ;
WO 2006/136442 A1
反应条件
in methanol; dichloromethane; N,N-dimethyl-formamide
参考文献
Cell Therapeutics, Inc.
Patent: US2003/153570 A1, 2003 ;
反应条件
hydrogenchloride in water; acetone
参考文献
Merck and Co., Inc.
Patent: US4760086 A1, 1988 ;
反应条件
thionyl chloride Heating;
参考文献
METABOLEX, INC.
Patent: WO2005/80340 A1, 2005 ;
Location in patent: Page/Page column 45 ;
反应条件
N,N-dimethyl-formamide in dichloromethane
参考文献
Wagenen, Bradford Van; Stormann, Thomas M.; Moe, Scott T.; Sheehan, Susan M.; McLeod, Donald A.; Smith, Daryl L.; Isaac, Methvin Benjamin; Slassi, Abdelmalik
Patent: US2003/55085 A1, 2003 ;
US 20030055085 A1
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Bigler,A.J. et al.
European Journal of Medicinal Chemistry, 1977 , vol. 12, p. 289 - 295
反应条件
1: 83 percent / CuBr, NaOMe / 24 h / 70 °C 2: NaOH / methanol; H2O / 3 h / Ambient temperature 3: ethyl acetate / 6 h / 65 °C 4: 1.34 g / LiAlH4 / tetrahydrofuran / 16 h / Heating 5: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 6: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
sulfuric acid; nitric acid T=90°C; 1.18333 h;
参考文献
THE UNIVERSITY OF QUEENSLAND; COOPER, Matthew; ZUEGG, Johannes; BECKER, Bernd; TOMISLAV, Karoli
Patent: WO2013/38259 A1, 2013 ;
Location in patent: Page/Page column 12 ;
