hydrogenchloride; thionyl chloride; sodium in ethanol

acetic acid in water 1.) steam bath, 6 h, 2.) room temperature, overnight; Yield given;

1: AcOH / H2O / 1.) steam bath, 6 h, 2.) room temperature, overnight 2: 19.12 g / AcOH / 4 h View Scheme

1: AcOH / H2O / 1.) steam bath, 6 h, 2.) room temperature, overnight 2: AcOH / 4 h View Scheme

1: AcOH / H2O / 1.) steam bath, 6 h, 2.) room temperature, overnight 2: AcOH / 4 h 3: 2.6 g / thionyl chloride / 16 h / Ambient temperature View Scheme

1: AcOH / H2O / 1.) steam bath, 6 h, 2.) room temperature, overnight 2: 19.12 g / AcOH / 4 h 3: 5.89 g / H2O, conc. aq. NH4OH, porcine renal acylase I, cobaltous acetate tetrahydrate / 96 h / 37 °C / pH 7-7.5 View Scheme