N-叔丁氧羰基-3-[(苄氧羰基)氨基]-L-丙氨酸合成路线 （共 22 条）
反应条件
potassium hydroxide; potassium carbonate in tetrahydrofuran; water
参考文献
More, Swati S.; Vince, Robert
Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4650 - 4656
反应条件
sodium carbonate in 1,4-dioxane; water T=25°C; 3 h;
参考文献
Cephalon, Inc.
Patent: US2006/189806 A1, 2006 ;
Location in patent: Page/Page column 44 ;
反应条件
sodium hydroxide in methanol T=20°C;
参考文献
Teng, Hanbing; Jiang, Zhengguo; Wu, Lamei; Su, Jiangtao; Feng, Xichun; Qiu, Guofu; Liang, Shucai; Hu, Xianming
Synthetic Communications, 2006 , vol. 36, # 24 p. 3803 - 3807
反应条件
sodium hydroxide in methanol; water 2 h;
参考文献
Organic Letters, , vol. 6, # 2 p. 213 - 215
反应条件
1: 98 percent / K2CO3 / dimethylformamide / 30 h / 0 °C 2: 96 percent / DMAP / acetonitrile / 24 h 3: 89 percent / H2 / Pd/C / methanol / 2 h / 2585.74 Torr 4: Et3N / tetrahydrofuran / 0.5 h / -10 °C 5: tetrahydrofuran; H2O / 1.5 h / -10 °C 6: 2.52 g / toluene / 2 h / Heating 7: 95 percent / CuCl / dimethylformamide / 1 h 8: 10 percent / NaOH / methanol; H2O / 2 h View Scheme
参考文献
Organic Letters, , vol. 6, # 2 p. 213 - 215
反应条件
1: 96 percent / DMAP / acetonitrile / 24 h 2: 89 percent / H2 / Pd/C / methanol / 2 h / 2585.74 Torr 3: Et3N / tetrahydrofuran / 0.5 h / -10 °C 4: tetrahydrofuran; H2O / 1.5 h / -10 °C 5: 2.52 g / toluene / 2 h / Heating 6: 95 percent / CuCl / dimethylformamide / 1 h 7: 10 percent / NaOH / methanol; H2O / 2 h View Scheme
参考文献
Organic Letters, , vol. 6, # 2 p. 213 - 215
反应条件
1: 89 percent / H2 / Pd/C / methanol / 2 h / 2585.74 Torr 2: Et3N / tetrahydrofuran / 0.5 h / -10 °C 3: tetrahydrofuran; H2O / 1.5 h / -10 °C 4: 2.52 g / toluene / 2 h / Heating 5: 95 percent / CuCl / dimethylformamide / 1 h 6: 10 percent / NaOH / methanol; H2O / 2 h View Scheme
参考文献
Organic Letters, , vol. 6, # 2 p. 213 - 215
反应条件
1: 60 percent / bis<trifluoroacetoxy>-phenyliodine (2), pyridine / dimethylformamide; H2O / 3 h / Ambient temperature 2: 42 percent / NaHCO3 / H2O View Scheme
参考文献
Synthesis, , vol. No.4, p. 266 - 268
反应条件
sodium hydroxide in methanol 1 h;
参考文献
Gangopadhyay, A. K.; Mathur, K. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 483 - 484
反应条件
1: Et3N / tetrahydrofuran / 0.5 h / -10 °C 2: tetrahydrofuran; H2O / 1.5 h / -10 °C 3: 2.52 g / toluene / 2 h / Heating 4: 95 percent / CuCl / dimethylformamide / 1 h 5: 10 percent / NaOH / methanol; H2O / 2 h View Scheme
参考文献
Organic Letters, , vol. 6, # 2 p. 213 - 215
