5-氯-1-氧代-2,3-二氢-1H-茚-2-羧酸甲酯合成路线 （共 8 条）
反应条件
oxone in 1,4-dioxane; water T=60°C; 5 h;
参考文献
Yu, Jun; Cui, Jian; Zhang, Chi
European Journal of Organic Chemistry, 2010 , # 36 p. 7020 - 7026
反应条件
sodium hydride; tert-butyl alcohol in tetrahydrofuran
Heating;
参考文献
Wu, Fanghui; Li, Hongming; Hong, Ran; Deng, Li
Angewandte Chemie - International Edition, 2006 , vol. 45, # 6 p. 947 - 950
反应条件
sodium hydride in tetrahydrofuran
0.75 h; Heating / reflux;
参考文献
BRANDEIS UNIVERSITY
Patent: WO2005/121137 A1, 2005 ;
Location in patent: Page/Page column 125 ;
反应条件
hydrogenchloride; sodium methylate in water
参考文献
E. I. du Pont de Nemours and Company
Patent: US1705 H1, 1998 ;
反应条件
1: sulfuric acid
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
View Scheme
参考文献
Zhang, Lingzi; Zhang, Jiafu; Sun, Dequn
Asian Journal of Chemistry, 2012 , vol. 24, # 3 p. 1413 - 1414
反应条件
1: AlCl3, aluminium chloride
2: sulfuric acid
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
View Scheme
参考文献
Zhang, Lingzi; Zhang, Jiafu; Sun, Dequn
Asian Journal of Chemistry, 2012 , vol. 24, # 3 p. 1413 - 1414
反应条件
1.1: hydrogen; palladium 10 on activated carbon / methanol
2.1: trifluorormethanesulfonic acid / 25 °C / |Cooling with ice
3.1: sodium hydride / tetrahydrofuran / 0.33 h / |Inert atmosphere
3.2: |Inert atmosphere; |Reflux
View Scheme
参考文献
Cao, Weidi; Liu, Xiaohua; Peng, Ruixue; He, Peng; Lin, Lili; Feng, Xiaoming
Chemical Communications, 2013 , vol. 49, # 33 p. 3470 - 3472
反应条件
1.1: trifluorormethanesulfonic acid / 25 °C / |Cooling with ice
2.1: sodium hydride / tetrahydrofuran / 0.33 h / |Inert atmosphere
2.2: |Inert atmosphere; |Reflux
View Scheme
参考文献
Cao, Weidi; Liu, Xiaohua; Peng, Ruixue; He, Peng; Lin, Lili; Feng, Xiaoming
Chemical Communications, 2013 , vol. 49, # 33 p. 3470 - 3472
