反应条件
1: 4-chloro-benzyl chloride With iodine; magnesium in diethyl ether
1.5 h; Heating;
2: 2,4-dichlorophenyl cyanide in toluene
T=135°C; Grignard reaction; 2 h;
3: With hydrogenchloride; water in toluene
参考文献
Lange, Jos H. M.; Van Stuivenberg, Herman H.; Coolen, Hein K. A. C.; Adolfs, Tiny J. P.; McCreary, Andrew C.; Keizer, Hiskias G.; Wals, Henri C.; Veerman, Willem; Borst, Alice J. M.; De Looff, Wouter; Verveer, Peter C.; Kruse, Chris G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1823 - 1838